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Introduction

We aim to provide easy access to recent cumulative published knowledge in biomarkers for Duchenne muscular dystrophy (DMD). This is a freely available electronic database which includes evidence from serum and tissue biomarkers.

The promise of biomarkers is immense, but often hampered by low powered analyses, especially in rare diseases like muscular dystrophies. The goal is to provide a searchable, living, resource to get an overview of current evidence around biomarkers in DMD.

Citation

   Coming soon!

Currently, this database includes data:

• Provided with UniProt, QuickGO, Human Protein Atlas etc., IDs, with external links to Gene Ontology, and UniProt for each target.
• Focused on Duchenne muscular dystrophy and the following questions:
  • Which biomarkers behave similarly, i.e., have similar expression trends?
  • Which biomarkers are different between boys with DMD and healthy controls?
  • Which biomarkers respond to therapeutics, e.g., steroids?
  • Which biomarkers are associated with age?
  • Which biomarkers are associated with clinical outcomes?
• On >3500 biomarker targets, with a large focus on circulating serum protein markers but also on tissue-based mRNAs.
• From different technologies: mass spectrometry, aptamer-based protein screens, Affymetrix gene expression arrays, etc.
• More features are planned, e.g., data from animal models, inclusion of other muscular dystrophies, etc.

Contact

   Want to contribute to this resource via annotated datasets or ideas for further development? Please contact utkarshdang@cunet.carleton.ca